Rhodiola (Rhodiola rosea) is a plant widely distributed at high altitudes in mountainous regions of Europe and Asia. It belongs to the family Crassulaceae. It has been used in traditional medicine to alleviate the following:
Rhodiola is also an adaptogen because it increases the body’s resistance to stress, such as environmental stressors, including oxidative stress, anxiety, and physical exercise. Kidney Bean EXTRACT
Laboratory studies indicate that the mood-enhancing effect of rhodiola appears to be due to the stimulation of norepinephrine, serotonin, dopamine, and acetylcholine receptors in the brain regions responsible for regulating mood and affect.
Furthermore, the ability of rhodiola to increase endogenous β-endorphin levels explains its antidepressant effect.
Rhodiola also blocks monoamine oxidase A and B enzyme activity. These enzymes break down neurotransmitters like serotonin, norepinephrine, and dopamine. Preventing the breakdown of these enzymes, in turn, increases the levels of neurotransmitters, which helps regulate mood.
This article discusses the potential uses of rhodiola. It also covers the side effects and precautions of taking such supplements.
Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian nutritionist (RDN), pharmacist, or healthcare provider. No supplement is intended to treat, cure, or prevent disease.
Rhodiola has been studied in the setting of depression, stress-related fatigue, and exercise performance.
In a 12-week clinical trial consisting of 57 participants, rhodiola has been shown to produce less antidepressant effect compared to Zoloft (sertraline), a conventional antidepressant therapy. However, rhodiola has a more favorable side effect profile compared to Zoloft.
Because rhodiola has better tolerability than Zoloft, the researchers suggested that rhodiola can potentially serve as a treatment alternative for people who are intolerant to the side effects of conventional antidepressants.
However, the study was limited in that it looked at people with mild to moderate major depressive disorder (MDD). Thus, it is unclear if people with more severe MDD would benefit from rhodiola.
A 12-week study consisting of 100 participants aged 18 to 50 years with mild to moderate depression compared the antidepressant effect among the control group (one sertraline tablet + two placebo capsules), the high-dose rhodiola group (one sertraline tablet + two rhodiola capsules), and the low-dose rhodiola group (one sertraline tablet + one placebo + one rhodiola capsule).
Among the three groups, people with mild to moderate depression taking high-dose rhodiola daily showed the greatest reduction of symptoms of depression over 12 weeks.
Further studies investigating the efficacy and safety of rhodiola in people with severe MDD and people over 50 years old would be needed to determine if rhodiola is effective in such a population.
The effect of rhodiola on stress-related fatigue was evaluated in 60 people aged 20–55 years old over 28 days. Compared with the placebo group, the rhodiola group showed a significant positive change in fatigue symptoms in people with stress-related fatigue. Additionally, levels of cortisol (a stress hormone) reduced significantly following 28 days of treatment with rhodiola.
More rigorous studies examining the efficacy of rhodiola in reducing stress-related fatigue are needed to confirm such a finding.
Short-term supplementation of rhodiola in 10 resistance-trained male participants increased the average barbell speed during bench press exercise compared to placebo.
Despite the enhancement of resistance exercise performance, it is essential to note that the sample size is small, and it is unclear if the results will translate to untrained people or females.
Another study examined the effects of rhodiola supplementation on anaerobic exercise performance in eleven female participants aged 18 to 24 years.
The study found that supplementing rhodiola over three days and 30 minutes before the exercise trial increased anaerobic capacity. This enhanced anaerobic exercise performance.
However, further studies with larger sample sizes and more diverse populations are needed to clarify the role of rhodiola in enhancing anaerobic exercise performance.
Your provider may recommend you take rhodiola for stress, mood, or stamina support. However, consuming a supplement like rhodiola may have potential side effects. These side effects may be common or severe.
Minimal to no side effects were reported in clinical trials.
Common side effects of rhodiola reported in some studies include the following:
No serious side effects were reported in clinical trials.
If you're having a severe allergic reaction or if any of your symptoms feel life-threatening, call 911 and get medical help right away.
Keep the following precautions in mind when using an rhodiola supplement:
The following were excluded in some clinical trials, and, therefore, the efficacy and safety of rhodiola in such a context are unclear:
Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs.
For depression: A dose escalation was used in a clinical study with the following schedule:
Another study looked at sertraline in combination with high-dose or low-dose rhodiola. The high-dose group consisted of one sertraline tablet (unclear dose) with two rhodiola capsules of 0.6 grams (g) per day given by mouth daily for 12 weeks.
The low-dose group consisted of one sertraline tablet (the dose is unclear) with one rhodiola capsule (0.3 g per day) given by mouth daily for 12 weeks.
For stress-related fatigue: The dose used in the clinical study was two tablets of rhodiola extract given by mouth in the morning and two tablets given by mouth at lunchtime (for a total of 576 mg extract daily) over 28 days.
For exercise performance: The dose used in clinical trials was a 500 mg capsule of rhodiola extract given by mouth three times daily (a total of 1,500 mg per day) for three days before each trial; an additional 500 mg dose was taken by mouth thirty minutes before each exercise trial.
The daily dose used in clinical trials ranges from 364 to 1,500 mg.
Previous studies of rhodiola have reported long-term supplementation of up to 680 mg is safe and tolerable.
However, it is important to note that nitrile compounds in rhodiola may pose a safety risk when rhodiola is used long-term.
Rhodiola rosea may interact with the following:
Serotonergic medications: Theoretically, taking rhodiola concurrently with drugs, such as Paxil (paroxetine), may increase the risk of a rare but serious condition called serotonin syndrome. While the clinical significance of such drug-herb interaction remains unclear, Zoloft (a serotonergic drug) has been used concurrently with rhodiola in a clinical study.
However, the concurrent use of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) has been purported to decrease common antidepressant side effects such as poor memory, sexual dysfunction, and weight gain.
When rhodiola extract is given with tricyclic antidepressants, such as Elavil (amitriptyline), there is a reduction in the side effects of the drugs and a positive effect on mood symptoms.
Drugs metabolized by the CYP2C9 enzyme: Rhodiola rosea has been shown to block the activity of the CYP2C9 enzyme in humans, thereby increasing the levels of drugs metabolized by such an enzyme. Some of the drugs metabolized by the CYP2C9 enzyme include Cozaar (losartan), Dilantin (phenytoin), and Jantoven (warfarin). Although the clinical significance is unclear, caution should be taken for high-risk drugs, such as Dilantin and Jantoven.
Additionally, extracts of rhodiola have been found to block the activity of CYP3A4, CYP2D6, and P-glycoprotein (P-gp) based on a test-tube study. Therefore, caution should be taken when combining rhodiola supplement with drugs (especially central nervous system drugs) associated with CYP3A4, CYP2D6, and P-gp.
Stimulant medications: Rhodiola rosea may have an additive effect with other stimulants.
It is essential to carefully read a supplement's ingredients list and nutrition facts panel to know which ingredients and how much of each ingredient is included. Please review the supplement label with your healthcare provider to discuss potential interactions with foods, other supplements, and medications.
Other supplements with similar properties to rhodiola include the following:
Like rhodiola, ashwagandha, Asian ginseng, Siberian ginseng, maral root, and schisandra are considered plant adaptogens (substances that help the body cope with mental and physical stress).
Some stress support supplements use a combination of adaptogenic herbs.
While green tea, magnesium, and B vitamins are not considered adaptogens, they are similar to rhodiola because they possess stress-relieving effects.
Unlike rhodiola, green tea, and magnesium, evidence from an analysis of a collection of studies suggests that B vitamins do not benefit anxiety.
Rhodiola is available through supplements.
As most of the human clinical studies use standardized extracts of rhodiola that include the entire spectrum of chemical constituents, look for products with 3% rosavin and 1% salidroside.
Rhodiola supplements are available in tablets, capsules, and liquid extracts.
Animal studies have shown that piperine, a compound found in black pepper, increases the absorption of rosavin and salidroside, both active compounds found in rhodiola. You may see some rhodiola supplements with black pepper extract added in for enhanced absorption.
Because rhodiola can cause sleep disturbances or vivid dreams, it should be taken early in the day during the first few weeks.
Rhodiola rosea is best taken on an empty stomach at least 30 minutes before breakfast and lunch.
Research on rhodiola, an adaptogenic herb, has shown promising results in depression, stress, fatigue, and exercise endurance. While rhodiola is generally tolerable, it should be avoided if you have certain medical conditions, such as bipolar disorder, or take certain prescription drugs. Consult with your healthcare provider to determine if a rhodiola supplement is appropriate.
Evidence from research studies has shown that rhodiola improves mood in people with mild to moderate depression.
Considered an adaptogen, rhodiola has also been shown to play a role in reducing stress and fatigue.
Rhodiola is medically established as a safe and effective anti-fatigue drug in Russia. Moreover, the Pharmacological and Pharmacopoeia Committee of the Soviet Ministry of Health recommended the medicinal use of rhodiola.
While more research is needed, some studies have shown that rhodiola improves exercise endurance.
Consult with your healthcare provider before starting rhodiola supplements, especially if you have certain health conditions, including bipolar disorder, psychotic disorders, anxiety, a substance use disorder or dependence disorder, or dementia.
Also speak to a medical professional first if you have had a severe allergic reaction to R. rosea, are pregnant or breastfeeding, are of childbearing potential and not using an acceptable form of contraception, and are younger than 18 years old.
Since rhodiola increases serotonin and norepinephrine levels, it can theoretically produce an additive effect when used concurrently with serotonergic and stimulant medication, respectively.
Rhodiola rosea has been shown to decrease the activity of the CYP2C9 enzyme, which may increase the levels of drugs metabolized by such an enzyme.
Please consult with your healthcare provider before starting rhodiola if you take medications such as Cozaar (losartan), Dilantin (phenytoin), or Jantoven (warfarin); stimulants; chemotherapy; MAOIs (within 14 days); and antidepressants, mood stabilizers, or antipsychotics.
Gao L, Wu C, Liao Y, Wang J. Antidepressants effects of Rhodiola capsule combined with sertraline for major depressive disorder: A randomized double-blind placebo-controlled clinical trial. J Affect Disord. 2020;265:99-103. doi:10.1016/j.jad.2020.01.065
Cropley M, Banks AP, Boyle J. The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytother Res. 2015;29(12):1934-1939. doi:10.1002/ptr.5486
Ballmann CG, Maze SB, Wells AC, et al. Effects of short-term Rhodiola rosea (golden root extract) supplementation on anaerobic exercise performance. J Sports Sci. 2019;37(9):998-1003. doi:10.1080/02640414.2018.1538028
Mao JJ, Xie SX, Zee J, et al. Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial. Phytomedicine. 2015;22(3):394-399. doi:10.1016/j.phymed.2015.01.010
Kosakowska O, Bączek K, Przybył JL, et al.Antioxidant and antibacterial activity of roseroot (Rhodiola rosea L.) dry extracts.Molecules.2018;23(7):1767.doi:10.3390/molecules23071767
National Center for Complementary and Integrative Health. Rhodiola.
Pu WL, Zhang MY, Bai RY, et al. Anti-inflammatory effects of Rhodiola rosea L.: A review. Biomed Pharmacother. 2020;121:109552. doi:10.1016/j.biopha.2019.109552
Ross SM. Rhodiola rosea (SHR-5), part I: A proprietary root extract of Rhodiola rosea is found to be effective in the treatment of stress-related fatigue. Holist Nurs Pract. 2014;28(2):149-154. doi:10.1097/HNP.0000000000000014
Williams TD, Langley HN, Roberson CC, et al. Effects of short-term golden root extract (Rhodiola rosea) supplementation on resistance exercise performance. Int J Environ Res Public Health. 2021;18(13):6953. doi:10.3390/ijerph18136953
Ross SM. Rhodiola rosea (SHR-5), part 2: A standardized extract of Rhodiola rosea is shown to be effective in the treatment of mild to moderate depression. Holist Nurs Pract. 2014;28(3):217-221. doi:10.1097/HNP.0000000000000030
Punja S, Shamseer L, Olson K, Vohra S. Rhodiola rosea for mental and physical fatigue in nursing students: a randomized controlled trial. PLoS One. 2014;9(9):e108416. doi:10.1371/journal.pone.0108416
Tao H, Wu X, Cao J, et al. Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study. Med Res Rev. 2019;39(5):1779-1850. doi:10.1002/med.21564
Thu OK, Spigset O, Nilsen OG, Hellum B. Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Eur J Clin Pharmacol. 2016;72(3):295-300. doi:10.1007/s00228-015-1988-7
Le TT, McGrath SR, Fasinu PS. Herb-drug interactions in neuropsychiatric pharmacotherapy - A review of clinically relevant findings. Curr Neuropharmacol. 2022;20(9):1736-1751. doi:10.2174/1570159X19666210809100357
Thu OK, Nilsen OG, Hellum B. In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products. Pharm Biol. 2016;54(12):3249-3256. doi:10.1080/13880209.2016.1223145
Khanum F, Bawa AS, Singh B. Rhodiola rosea: A versatile adaptogen. Compr Rev Food Sci Food Saf. 2005;4(3):55-62. doi:10.1111/j.1541-4337.2005.tb00073.x
Todorova V, Ivanov K, Delattre C, Nalbantova V, Karcheva-Bahchevanska D, Ivanova S. Plant adaptogens-History and future perspectives.Nutrients.2021;13(8):2861.doi:10.3390/nu13082861
Boyle NB, Billington J, Lawton C, Quadt F, Dye L. A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers. Nutr Neurosci. 2022;25(9):1845-1859. doi:10.1080/1028415X.2021.1909204
Young LM, Pipingas A, White DJ, Gauci S, Scholey A. A systematic review and meta-analysis of B vitamin supplementation on depressive symptoms, anxiety, and stress: Effects on healthy and ‘at-risk’ individuals. Nutrients. 2019;11(9):2232. doi:10.3390/nu11092232
Panossian A, Nikoyan N, Ohanyan N, et al. Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine. 2008;15(1-2):84-91. doi:10.1016/j.phymed.2007.10.003
By Trang Tran, PharmD Trang Tran, PharmD, is a pharmacist who is passionate about integrative health.
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